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Novel treatment predictive factors identified Green, Henrik Linköpings universitet, Institutionen för medicin och hälsa, Klinisk farmakologi. The diffusion-controlled release kinetics of the drug from the NPs interestingly depended on the nature of the core moiety. Eight fluorinated nanoparticles NPs are synthesized, loaded with doxorubicin DOXand evaluated as theranostic delivery platforms to breast cancer cells. Well-controlled polymers with interesting tunable thermo-responsive properties were accomplished by altering the monomer feed ratio. The aim of this work was to design and synthesize amphiphilic ethylene glycol methacrylate-based EGMA macromolecules, and explore their potential as NPs for drug delivery. We investigated the efficacy and safety of single-agent pegylated liposomal doxorubicin PLD as first-line treatment for elderly women with advanced breast cancer and evaluated predictive markers for response and toxicity.

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The aim of this work was to design and synthesize amphiphilic ethylene glycol methacrylate-based EGMA macromolecules, and explore their potential as NPs for drug delivery.

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Initially, a study of the controlled synthesis and solution properties of linear EGMA polymers, as well as the potential to transfer their behavior to amphiphilic comb copolymers, was conducted. Enkel sökning Avancerad sökning - Forskningspublikationer Avancerad sökning - Studentuppsatser Statistik. Karolinska University Hospital, Stockholm. Visa övriga samt affilieringar. Also potential predictive markers were identified. The multifunctional NPs are formed by self-assembly of either linear or star-shaped amphiphilic block copolymers, with fluorinated segments incorporated in the hydrophilic corona of the carrier.

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